Unknown

Dataset Information

0

Progress in Stereoselective Construction of C-C Bonds Enabled by Aldolases and Hydroxynitrile Lyases.


ABSTRACT: The creation of C-C bonds is an effective strategy for constructing complex compounds from simple synthetic blocks. Although many methods have been developed for C-C bond construction, the stereoselective creation of new C-C bonds remains a challenge. The selectivities (enantioselectivity, regioselectivity, and chemoselectivity) of biocatalysts are higher than those of chemical catalysts, therefore biocatalysts are excellent candidates for use in stereoselective C-C bond formation. Here, we summarize progress made in the past 10 years in stereoselective C-C bond formation enabled by two classic types of enzyme, aldolases and hydroxynitrile lyases. The information in this review will enable the development of new routes to the stereoselective construction of C-C bonds.

SUBMITTER: Liu M 

PROVIDER: S-EPMC8097096 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5466365 | biostudies-literature
| S-EPMC3298160 | biostudies-literature
| S-EPMC5546752 | biostudies-literature
| S-EPMC5813103 | biostudies-literature
| S-EPMC3444685 | biostudies-literature
| S-EPMC4821162 | biostudies-literature
| S-EPMC8163235 | biostudies-literature
| S-EPMC6679931 | biostudies-literature
| S-EPMC3326629 | biostudies-literature
| S-EPMC10882986 | biostudies-literature