Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC8115645 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Huang Xinfang X Hao Shumeng S Liu Junli J Huang Yuanyuan Y Liu Manman M Xiao Chunyuan C Wang Yan Y Pei Siyu S Yu Tao T Xu Jing J Wang Haikun H Dai Dongfang D Su Xiao X Xiao Yichuan Y
Cellular & molecular immunology 20210311 4
T follicular helper (Tfh) cells are crucial for regulating autoimmune inflammation and protective immunity against viral infection. However, the molecular mechanism controlling Tfh cell differentiation is poorly understood. Here, through two mixed bone marrow chimeric experiments, we identified Peli1, a T cell-enriched E3 ubiquitin ligase, as an intrinsic regulator that inhibits Tfh cell differentiation. Peli1 deficiency significantly promoted c-Rel-mediated inducible T-cell costimulator (ICOS) ...[more]