Ontology highlight
ABSTRACT:
SUBMITTER: Chang M
PROVIDER: S-EPMC3178748 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Nature immunology 20110828 10
T cell activation is subject to tight regulation to avoid inappropriate responses to self antigens. Here we show that genetic deficiency in the ubiquitin ligase Peli1 caused hyperactivation of T cells and rendered T cells refractory to suppression by regulatory T cells and transforming growth factor-β (TGF-β). As a result, Peli1-deficient mice spontaneously developed autoimmunity characterized by multiorgan inflammation and autoantibody production. Peli1 deficiency resulted in the nuclear accumu ...[more]