Ontology highlight
ABSTRACT:
SUBMITTER: Xiong P
PROVIDER: S-EPMC8119458 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Xiong Peng P Wu Ruibo R Zhan Jian J Zhou Yaoqi Y
Nature communications 20210513 1
Refining modelled structures to approach experimental accuracy is one of the most challenging problems in molecular biology. Despite many years' efforts, the progress in protein or RNA structure refinement has been slow because the global minimum given by the energy scores is not at the experimentally determined "native" structure. Here, we propose a fully knowledge-based energy function that captures the full orientation dependence of base-base, base-oxygen and oxygen-oxygen interactions with t ...[more]