Novel loci and pathways significantly associated with longevity.
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ABSTRACT:
SUBMITTER: Zeng Y
PROVIDER: S-EPMC4766491 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Novel loci and pathways significantly associated with longevity.
Zeng Yi Y Nie Chao C Min Junxia J Liu Xiaomin X Li Mengmeng M Chen Huashuai H Xu Hanshi H Wang Mingbang M Ni Ting T Li Yang Y Yan Han H Zhang Jin-Pei JP Song Chun C Chi Li-Qing LQ Wang Han-Ming HM Dong Jie J Zheng Gu-Yan GY Lin Li L Qian Feng F Qi Yanwei Y Liu Xiao X Cao Hongzhi H Wang Yinghao Y Zhang Lijuan L Li Zhaochun Z Zhou Yufeng Y Wang Yan Y Lu Jiehua J Li Jianxin J Qi Ming M Bolund Lars L Yashin Anatoliy A Land Kenneth C KC Gregory Simon S Yang Ze Z Gottschalk William W Tao Wei W Wang Jian J Wang Jun J Xu Xun X Bae Harold H Nygaard Marianne M Christiansen Lene L Christensen Kaare K Franceschi Claudio C Lutz Michael W MW Gu Jun J Tan Qihua Q Perls Thomas T Sebastiani Paola P Deelen Joris J Slagboom Eline E Hauser Elizabeth E Xu Huji H Tian Xiao-Li XL Yang Huanming H Vaupel James W JW
Scientific reports 20160225
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, i ...[more]
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