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Novel loci and pathways significantly associated with longevity.


ABSTRACT: Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, including two novel loci (rs2069837-IL6; rs2440012-ANKRD20A9P) with genome-wide significance and the rest with suggestive significance (P?

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC4766491 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Novel loci and pathways significantly associated with longevity.

Zeng Yi Y   Nie Chao C   Min Junxia J   Liu Xiaomin X   Li Mengmeng M   Chen Huashuai H   Xu Hanshi H   Wang Mingbang M   Ni Ting T   Li Yang Y   Yan Han H   Zhang Jin-Pei JP   Song Chun C   Chi Li-Qing LQ   Wang Han-Ming HM   Dong Jie J   Zheng Gu-Yan GY   Lin Li L   Qian Feng F   Qi Yanwei Y   Liu Xiao X   Cao Hongzhi H   Wang Yinghao Y   Zhang Lijuan L   Li Zhaochun Z   Zhou Yufeng Y   Wang Yan Y   Lu Jiehua J   Li Jianxin J   Qi Ming M   Bolund Lars L   Yashin Anatoliy A   Land Kenneth C KC   Gregory Simon S   Yang Ze Z   Gottschalk William W   Tao Wei W   Wang Jian J   Wang Jun J   Xu Xun X   Bae Harold H   Nygaard Marianne M   Christiansen Lene L   Christensen Kaare K   Franceschi Claudio C   Lutz Michael W MW   Gu Jun J   Tan Qihua Q   Perls Thomas T   Sebastiani Paola P   Deelen Joris J   Slagboom Eline E   Hauser Elizabeth E   Xu Huji H   Tian Xiao-Li XL   Yang Huanming H   Vaupel James W JW  

Scientific reports 20160225


Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, i  ...[more]

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