Correlation between TLR4 gene polymorphism and acute respiratory distress syndrome after esophageal cancer surgery.

ABSTRACT:

Background

One of the major postoperative complications of esophageal cancer is acute respiratory distress syndrome (ARDS), which poses a great threat to patients' lives. In this research, the cause of ARDS after esophageal cancer surgery was explained from the aspect of the single-nucleotide polymorphism at rs7873784, rs10759930 and rs10983755 of the Toll-like receptor 4 (TLR4) gene.

Methods

A total of 75 patients complicated with ARDS after esophageal cancer surgery in our hospital were collected as the ARDS group and 150 patients without ARDS after surgery as the control group. Deoxyribonucleic acids (DNAs) in the peripheral blood of patients were extracted, and the polymorphism loci (rs7873784, rs10759930 and rs10983755) of the TLR4 gene were amplified through polymerase

SUBMITTER: Wang T 

PROVIDER: S-EPMC8129334 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature