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From 1,2-difunctionalisation to cyanide-transfer cascades - Pd-catalysed cyanosulfenylation of internal (oligo)alkynes.

ABSTRACT: Internal alkynes substituted by aliphatic or aromatic moieties or by heteroatoms were converted into sulphur-substituted acrylonitrile derivatives. Key is the use of Pd catalysis, which allows the addition of aromatic and aliphatic thiocyanates in an intra- and intermolecular manner. Substrates with several alkyne units underwent further carbopalladation steps after the initial thiopalladation step, thus generating in a cascade-like fashion an oligoene unit with sulphur at one terminus and the cyano group at the other.

SUBMITTER: Burger M

PROVIDER: S-EPMC8148069 | biostudies-literature |

REPOSITORIES: biostudies-literature

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