Vaccine-induced ICOS⁺CD38⁺ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.

ABSTRACT: Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective humoral immunity. We performed transcriptional profiling and cellular analysis on circulating Tfh before and after influenza vaccination in young and elderly adults. First, whole-blood transcriptional profiling shows that ICOS⁺CD38⁺ cTfh following vaccination preferentially enriches in gene sets associated with youth versus aging compared to other circulating T cell types. Second, vaccine-induced ICOS⁺CD38⁺ cTfh from the elderly had increased the expression of g

SUBMITTER: Herati RS 

PROVIDER: S-EPMC8149371 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature