A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners.

ABSTRACT: RAS effectors specifically interact with GTP-bound RAS proteins to link extracellular signals to downstream signaling pathways. These interactions rely on two types of domains, called RAS-binding (RB) and RAS association (RA) domains, which share common structural characteristics. Although the molecular nature of RAS-effector interactions is well-studied for some proteins, most of the RA/RB-domain-containing proteins remain largely uncharacterized. Here, we searched through human proteome databases, extracting 41 RA domains in 39 proteins and 16 RB domains in 14 proteins, each of which can specifically select at least one of the 25 members in the RAS family. We next comprehensively investigated the sequence-structure-function relationship between different representatives of the RAS family

SUBMITTER: Rezaei Adariani S 

PROVIDER: S-EPMC8163975 | biostudies-literature | 2021 Jan-Jun

REPOSITORIES: biostudies-literature