Ontology highlight
ABSTRACT:
SUBMITTER: Rayner PJ
PROVIDER: S-EPMC8179664 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Rayner Peter J PJ Gillions Joseph P JP Hannibal Valentin D VD John Richard O RO Duckett Simon B SB
Chemical science 20210323 16
Signal Amplification by Reversible Exchange (SABRE) is a catalytic method for improving the detection of molecules by magnetic resonance spectroscopy. It achieves this by simultaneously binding the target substrate (sub) and <i>para</i>-hydrogen to a metal centre. To date, sterically large substrates are relatively inaccessible to SABRE due to their weak binding leading to catalyst destabilisation. We overcome this problem here through a simple co-ligand strategy that allows the hyperpolarisatio ...[more]