Diagnostic performance of ¹⁸F-DCFPyL positron emission tomography/computed tomography for biochemically recurrent prostate cancer and change-of-management analysis.

ABSTRACT:

Introduction

Conventional imaging (CI) performs poorly to identify sites of disease in biochemically recurrent prostate cancer. ⁶⁸Ga-PSMA-11 positron emission tomography/computed tomography (PET/CT) is most studied but has a very short half-life. This study reports the diagnostic performance of the novel prostate-specific membrane antigen (PSMA) radiotracer ¹⁸F-DCFPyL using real-life data and tumor board simulation to estimate the impact of ¹⁸F-DCFPyL PET on patient management.

Methods

Ninety-three ¹⁸F-DCFPyL PET/CT scans performed for patients previously treated for prostate cancer with a rising prostate-specific antigen (PSA) were retrospectively compared to contemporary CI and clinical imaging and PSA followups. A chart review was performed to document prior imaging, pathology results, serial serum PSA measurements, and other pertinent clinical data. Clinical utility of ¹⁸F-DCFPyL PET was measured using a simulated tumor board formed by three physicians with extensive prostate cancer experience deciding on management with and without knowledge of PET/CT results.

Results

At median PSA 2.27 (interquartile rage [IQR] 5.27], 82% of ¹⁸F-DCFPyL PET/CT demonstrated at least one site of disease: non-regional lymph nodes (37% of scans), regional lymph node metastases (28%), local recurrence (27%), and bone metastases (20%), with higher PET positivity at higher PSA. Compared to ¹⁸F-DCFPyL PET/CT, CI showed overall poor performance, with accuracy below 20% for all extent of disease. PET/CT changed management in 44% of cases. The most frequent scenario was a radical change from initiating androgen deprivation therapy (ADT) to stereotactic body radiotherapy (SBRT) of oligo-lesional disease. In univariate and multivariate analysis, no patient characteristic could predict change of management by PET/CT results.

Conclusions

¹⁸F-DCFPyL significantly outperforms CI in recurring prostate cancer and is likely to impact management.

SUBMITTER: Chausse G 

PROVIDER: S-EPMC8195586 | biostudies-literature |

REPOSITORIES: biostudies-literature