Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers.

ABSTRACT: Endometriosis is a common gynecological disorder that has been associated with endometrial, breast and epithelial ovarian cancers in epidemiological studies. Since complex diseases are a result of multiple environmental and genetic factors, we hypothesized that the biological mechanism underlying their comorbidity might be explained, at least in part, by shared genetics. To assess their potential genetic relationship, we performed a two-sample mendelian randomization (2SMR) analysis on results from public genome-wide association studies (GWAS). This analysis confirmed previously reported genetic pleiotropy between endometriosis and endometrial cancer. We present robust evidence supporting a causal genetic association between endometriosis and ovarian cancer, particularly with the clear cel

SUBMITTER: Rueda-Martinez A 

PROVIDER: S-EPMC8200110 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature