Unknown

Dataset Information

0

Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction.


ABSTRACT: Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Our results suggest that increased reproduction can be uncoupled from the costs of reproduction from somatic longevity regulation if provided with the limiting lipid, oleic acid.

SUBMITTER: Choi LS 

PROVIDER: S-EPMC8226236 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6719292 | biostudies-literature
2009-02-18 | E-GEOD-12834 | biostudies-arrayexpress
| S-EPMC6697448 | biostudies-literature
2009-02-19 | GSE12834 | GEO
| S-EPMC2937264 | biostudies-literature
2018-09-20 | GSE120223 | GEO
| S-EPMC7084183 | biostudies-literature
| S-EPMC4022182 | biostudies-literature
| S-EPMC6386356 | biostudies-literature
| PRJNA492174 | ENA