Ontology highlight
ABSTRACT:
SUBMITTER: Shi C
PROVIDER: S-EPMC6719292 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Shi Cheng C Murphy Coleen T CT
Science (New York, N.Y.) 20131219 6170
Interactions between the germ line and the soma help optimize reproductive success. We discovered a phenomenon linking reproductive status to longevity: In both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing postreproductive life span. Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibility, and subsequent life-span decrease, whereas seminal fluid induces DAF-16-dependent life-span decrease and fat ...[more]