Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO₂ NM).

ABSTRACT: Several reports on amorphous silica nanomaterial (aSiO₂ NM) toxicity have been questioning their safety. Herein, we investigated the in vivo pulmonary toxicity of four variants of aSiO₂ NM: SiO₂_15_Unmod, SiO₂_15_Amino, SiO₂_7 and SiO₂_40. We focused on alterations in lung DNA and protein integrity, and gene expression following single intratracheal instillation in rats. Additionally, a short-term inhalation study (STIS) was carried out for SiO₂_7, using TiO₂_NM105 as a benchmark NM. In the instillation study, a significant but slight increase in oxidative DNA damage in rats exposed to the highest instilled dose (0.36 mg/rat) of SiO₂_15_Amino was observed in the recovery (R) group. Exposure t

SUBMITTER: Brandao F 

PROVIDER: S-EPMC8228975 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature