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Enantioselective Copper-Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones.

ABSTRACT: Quinazolinones are common substructures in molecules of medicinal importance. We report an enantioselective copper-catalyzed borylative cyclization for the assembly of privileged pyrroloquinazolinone motifs. The reaction proceeds with high enantio- and diastereocontrol, and can deliver products containing quaternary stereocenters. The utility of the products is demonstrated through further manipulations.

SUBMITTER: Dherbassy Q

PROVIDER: S-EPMC8252434 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Enantioselective Copper-Catalyzed Borylative Cyclization for the Synthesis of Quinazolinones.

Dherbassy Quentin Q Manna Srimanta S Shi Chunling C Prasitwatcharakorn Watcharapon W Crisenza Giacomo E M GEM Perry Gregory J P GJP Procter David J DJ

Angewandte Chemie (International ed. in English) 20210519 26

Quinazolinones are common substructures in molecules of medicinal importance. We report an enantioselective copper-catalyzed borylative cyclization for the assembly of privileged pyrroloquinazolinone motifs. The reaction proceeds with high enantio- and diastereocontrol, and can deliver products containing quaternary stereocenters. The utility of the products is demonstrated through further manipulations. ...[more]

PMID: 33847459

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