A holistic seismotectonic model of Delhi region.
Ontology highlight
ABSTRACT:
SUBMITTER: Bansal BK
PROVIDER: S-EPMC8257579 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:The non-tectonic deformation, either of natural or anthropogenic origin, may influence the earthquake occurrence process and seismicity rate along the plate-boundary or 'stable' plate-interiors domains. The low magnitude but moderate seismicity rate of Delhi region on the stable plate-interiors domains of India, exhibits significant variation both in short-term at annual seasonal scale and in long-term at decadal scale. It correlates with the anthropogenic groundwater pumping for the extensive irrigation, urban activities, and seasonally controlled hydrological loading cycle of Indo-Ganga Basin hosted freshwater aquifers. Our coupled hydro-mechanical simulation and poro-mechanical analysis of basement fault stability suggest that the combined aquifer contraction and basement rock expansion act together to modulate the effective stress regime and anthropogenic seismicity on the basement faults in Delhi region.
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Project description:Background:Industries such as electroplating, mining and battery production are major sources of heavy metal-rich waste entering nearby water bodies. Irrigation with heavy metal contaminated water can deteriorate soil quality as well as agricultural produce and have further toxic effects on human health. Objectives:The objective of the present study was to estimate the concentration of hazardous heavy metals such as chromium (Cr), cadmium (Cd), copper (Cu), nickel (Ni), zinc (Zn) and lead (Pb), as well as physico-chemical variables (pH, electrical conductivity, total dissolved solids, chemical oxygen demand and dissolved oxygen) at sampling locations along the Najafgarh and Loha mandi drains in Delhi, National Capital Region, India. Methods:The present study evaluated the quality of wastewater from the Najafgarh and Loha mandi drains, which are used for irrigational purposes in the Delhi region. Drain water quality was monitored for a period of 2 years for physico-chemical variables (pH, chemical oxygen demand, electrical conductivity and dissolved oxygen) as well as heavy metal concentrations (Cr, Cu, Cd, Zn, Ni and Pb). The two-year monitoring period (July 2012-March 2014) was chosen to represent three seasons: pre-monsoon, monsoon, and post-monsoon. Results:Varied concentrations of multiple heavy metals were found due to the extensive discharge of untreated industrial effluents into the drain water. Punjabi Bagh of Najafgarh drain was the most contaminated sampling site with the maximum concentration of Zn (12.040 ± 0.361 mg L-1), followed by Cr (2.436 ± 0.073mg L-1) and Cu (2.617 ± 0.078 mg L-1). Conclusions:Consumption of heavy metal-contaminated agricultural products can cause deleterious human health effects, leading to further health problems. The presence of multi-heavy metal ions above the Food and Agriculture Organization of the United Nations (FAO) permissible limits indicated that drain water was not suitable for irrigational purposes, and adequate measures are required to remove the heavy metal load from drain water. Competing Interests:The authors declare no competing financial interests.
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Project description:Phosphate plays a chemically unique role in shaping cellular signaling of all current living systems, especially eukaryotes. Protein phosphorylation has been studied at several levels, from the near-site context, both in sequence and structure, to the crowded cellular environment, and ultimately to the systems-level perspective. Despite the tremendous advances in mass spectrometry and efforts dedicated to the development of ad hoc highly sophisticated methods, phosphorylation site inference and associated kinase identification are still unresolved problems in kinome biology. The sequence and structure of the substrate near-site context are not sufficient alone to model the in vivo phosphorylation rules, and they should be integrated with orthogonal information in all possible applications. Here we provide an overview of the different contexts that contribute to protein phosphorylation, discussing their potential impact in phosphorylation site annotation and in predicting kinase-substrate specificity.
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Project description:AimTo assess the level of adherence to diabetes care processes, and associated clinic and patient factors at general practices in Delhi, India.MethodsWe interviewed physicians (n = 23) and patients with diabetes (n = 406), and reviewed patient charts at general practices (government = 5; private = 18). We examined diabetes care processes, specifically measurement of weight, blood pressure (BP), glycated hemoglobin (HbA1c), lipids, electrocardiogram, dilated eye, and a foot examination in the last one year. We analyzed clinic and patient factors associated with a number of care processes achieved using multilevel Poisson regression model.ResultsThe average number of clinic visits per patient was 8.8/year (standard deviation = 5.7), and physicians had access to patient's previous records in only 19.7% of patients. Dilated eye exam, foot exam, and electrocardiogram were completed in 7.4%, 15.1%, and 29.1% of patients, respectively. An estimated 51.7%, 88.4%, and 28.1% had ≥1 measurement of HbA1c, BP, and lipids, respectively. Private clinics, physician access to patient's previous records, use of nonphysicians, patient education, and the presence of diabetes complication were positively associated with a number of care processes in the multivariable model.ConclusionAdherence to diabetes care processes was suboptimal. Encouraging implementation of quality improvement strategies like Chronic Care Model elements at general practices may improve diabetes care.
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Project description:The simulation of immune response is a challenging task because quantitative data are scarce. Quantitative theoretical models either focus on specific cell-cell interactions or have to make assumptions about parameters. The broad variation of, e.g., the dimensions and abundance between lymph nodes as well as between individual patients hampers conclusive quantitative modeling. No theoretical model has been established representing a consensus on the set of major cellular processes involved in the immune response. In this paper, we apply the Petri net formalism to construct a semi-quantitative mathematical model of the lymph nodes. The model covers the major cellular processes of immune response and fulfills the formal requirements of Petri net models. The intention is to develop a model taking into account the viewpoints of experienced pathologists and computer scientists in the field of systems biology. In order to verify formal requirements, we discuss invariant properties and apply the asynchronous firing rule of a place/transition net. Twenty-five transition invariants cover the model, and each is assigned to a functional mode of the immune response. In simulations, the Petri net model describes the dynamic modes of the immune response, its adaption to antigens, and its loss of memory.
| S-EPMC9953182 | biostudies-literature
Project description:There is an urgent need for a unified resource that integrates trans-disciplinary annotations of emerging and reemerging animal infectious and zoonotic diseases. Such data integration will provide wonderful opportunity for epidemiologists, researchers and health policy makers to make data-driven decisions designed to improve animal health. Integrating emerging and reemerging animal infectious and zoonotic disease data from a large variety of sources into a unified open-access resource provides more plausible arguments to achieve better understanding of infectious and zoonotic diseases. We have developed a model for interlinking annotations of these diseases. These diseases are of particular interest because of the threats they pose to animal health, human health and global health security. We demonstrated the application of this model using brucellosis, an infectious and zoonotic disease. Preliminary annotations were deposited into VetBioBase database (http://vetbiobase.igbb.msstate.edu). This database is associated with user-friendly tools to facilitate searching, retrieving and downloading of disease-related information. Database URL: http://vetbiobase.igbb.msstate.edu.
| S-EPMC4651161 | biostudies-literature
Project description:BackgroundFood policies and environment (availability, accessibility, affordability, marketing) in and around educational institutes can influence food choices and behaviours of children and adolescents.MethodsCross-sectional, mixed-methods study was implemented in schools (n = 9; Private = 6, Public = 3) and colleges (n = 4) from Delhi and National Capital Region (India). The data was collected from students of schools (n = 253) and colleges (n = 57), parents of school students (n = 190), teachers (n = 12, schools = 9, colleges = 3) and canteen operators of Private schools and colleges (n = 10; schools = 6, and colleges = 4). The primary and secondary data was collected to: 1) identify the strengths and weaknesses of the existing guidelines and directives (desk review); 2) examine food environment, existing policies and its implementation (structured observations, in-depth interviews, surveys, focus group discussions), and; 3) assess food choices, behaviours of students (focus group discussions). The thematic analysis was used for qualitative data and descriptive analysis for quantitative data.ResultsThe available food and beverage options, in and around the participating educational institutes were either high in fat, salt and sugar (HFSS), despite government and educational institute guidelines on restricting the availability and accessibility of HFSS foods. The healthy food and beverage options were expensive compared to HFSS foods both inside and outside educational institutes. In total, 37 vendors (Private = 27; Public:10) were observed outside schools at dispersal and twelve at lunchtime. Around colleges, vendors (n = 14) were seen throughout the day. Students from all Private schools (n = 6) and colleges (n = 2) were exposed to food and beverage advertisements either HFSS (Private schools = 1-3 and colleges = 0-2 advertisements), whereas no advertisements were observed around Public schools.ConclusionIt is imperative to implement food policies to improve the food environment in and around educational institutes to ensure the availability of healthy foods to establish and sustain healthy eating behaviours among students. Thus, the study findings emphasise stringent implementation, regular monitoring and surveillance of recently introduced Food Safety and Standards (Safe food and balanced diets for children in school) Regulation 2020, ensuring its compliance through effective enforcement strategies.
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Project description:Urban water and wastewater utilities are striving to improve their environmental and economic performances due to multiple challenges such as increasingly stringent quality criterion, aging infrastructure, constraining financial burden, growing urban population, climate challenges and dwindling resources. Growing needs of holistic assessments of urban water systems are required to identify systems-level cross-domain solutions. This study evaluated the life cycle environmental and economic impacts of urban water and wastewater systems with two utilities in Greater Cincinnati region as a case study. The scope of this study includes the entire urban water and wastewater systems starting from raw water acquisition for drinking water to wastewater treatment and discharge. The detailed process-based life cycle models were developed based on the datasets provided by local water and wastewater utilities. The life cycle assessment indicated that the operation and maintenance of drinking water distribution was a dominating contributor for energy consumption (43%) and global warming potential (41%). Wastewater discharge from the wastewater treatment plant contributed to more than 80% of the total eutrophication potential. The cost analysis determined that labor and maintenance cost (19%) for wastewater collection, and electricity cost (13%) for drinking water distribution were major contributors. Electricity purchased by the utility was the driver for the majority of impact categories assessed with the exception of eutrophication, blue water use, and metal depletion. Infrastructure requirements had a negligible influence on impact results, contributing less than 3% to most categories, with the exception of metal depletion where it led to 68% of total burdens. Sensitivity analysis showed that the life cycle environmental results were more sensitive to the choice of the electricity mixes and electricity consumption than the rest of input parameters such as chemical dosages, and infrastructure life time. This is one of the first comprehensive studies of the whole urban water system using real case data. It elucidates a bigger picture of energy, resource and cost distributions in a typical urban centralized water system. Inherent to a modern city as large population centers, a significant expenditure has to be invested to provide water services function (moving water, treating water/wastewater) in order to avoid human and environmental health problems. This study provides insights for optimization potentials of overall treatment efficiency and can serve as a benchmark for communities considering adoption of alternative water systems.
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