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A multicomponent tetrazolo indole synthesis.


ABSTRACT: The ubiquitous presence of the indole fragment in natural products and drugs asks for ever novel syntheses. We report an unprecedented mild, two-step synthesis of 2-tetrazolo substituted indoles based on the Ugi-tetrazole reaction combined with an acidic ring closure. A gram-scale synthesis, a bioactive compound and further transformations were performed.

SUBMITTER: Lei X 

PROVIDER: S-EPMC8259579 | biostudies-literature |

REPOSITORIES: biostudies-literature

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