Renal ^99mTc-DMSA pharmacokinetics in pediatric patients.

ABSTRACT: ^99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for ^99mTc-DMSA in children, and currently available pediatric dose estimates for ^99mTc-DMSA use pediatric S values with PK data derived from adults. Furthermore, the adult PK data were collected in the mid-70's using quantification techniques and instrumentation available at the time. Using pediatric imaging data for DMSA, we have obtained kinetic parameters for DMSA that differ from those applicable to adults.

Methods

We obtained patient data from a retrospective re-evaluation of clinically collected pediatric SPECT images of ^99mTc-DMSA in 54 pediatric patients from Boston's Children Hospital (BCH),

SUBMITTER: Plyku D 

PROVIDER: S-EPMC8292521 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature