Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
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ABSTRACT: Introduction
In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD).Methods
Step activity (monitored for 7 days), functional ability, and strength were quantified in ambulatory boys (5-12.9 years of age) with DMD and unaffected boys. Ambulatory status was determined 2 years later.Results
Two to 5 days of activity monitoring predicted weekly step activity (adjusted R2 = 0.80-0.95). Age comparisons revealed significant declines for step activity with increasing age, and relationships were found between step activity with both function and strength (P < .01). Our regression model predicted 36.5% of the variance in step activity. Those who were still ambulatory after 2 years demonstrated baseline step activity nearly double that of those who were no longer walking 2 years later (P < .01).Discussion
Step activity for DMD is related to and predictive of functional declines, which may be useful for clinical trials.
SUBMITTER: Lott DJ
PROVIDER: S-EPMC8314165 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Walking activity in a large cohort of boys with Duchenne muscular dystrophy.
Lott Donovan J DJ Taivassalo Tanja T Senesac Claudia R CR Willcocks Rebecca J RJ Harrington Ann M AM Zilke Kirsten K Cunkle Hilary H Powers Catherine C Finanger Erika L EL Rooney William D WD Tennekoon Gihan I GI Vandenborne Krista K
Muscle & nerve 20201127 2
<h4>Introduction</h4>In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD).<h4>Methods</h4>Step activity (monitored for 7 days), functional ability, and strength were quantified in ambulatory boys (5-12.9 years of age) with DMD and unaffected boys. Ambulatory status was determined 2 years later.<h4>Results</h4>Two to 5 days of activity monitoring predicted weekly step activity (adjusted R<sup>2</sup> = 0.80-0.95). Age comparisons revealed sig ...[more]
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