Ontology highlight
ABSTRACT:
SUBMITTER: Kavalakatt S
PROVIDER: S-EPMC8329193 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Kavalakatt Sina S Khadir Abdelkrim A Madhu Dhanya D Koistinen Heikki A HA Al-Mulla Fahd F Tuomilehto Jaakko J Abubaker Jehad J Tiss Ali A
Scientific reports 20210802 1
The neuropeptide urocortin 3 (UCN3) has a beneficial effect on metabolic disorders, such as obesity, diabetes, and cardiovascular disease. It has been reported that UCN3 regulates insulin secretion and is dysregulated with increasing severity of obesity and diabetes. However, its function in the adipose tissue is unclear. We investigated the overexpression of UCN3 in 3T3-L1 preadipocytes and differentiated adipocytes and its effects on heat shock response, ER stress, inflammatory markers, and gl ...[more]