Serotonin system genes contribute to the susceptibility to obesity in Black adolescents.

ABSTRACT:

Objective

The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose of this study was to investigate the association of genes within both serotonin systems with obesity outcomes in black adolescents.

Methods

African-American adolescents (n = 1052) whose mothers participated the Memphis New Mother's Study were assessed. In total, 110 polymorphisms mapped to 10 serotonin genes were examined for their associations with standardized body mass index (BMI-z) scores and waist circumferences using generalized estimating equation models.

Results

Over 39% of adolescents were ov

SUBMITTER: Meng Y 

PROVIDER: S-EPMC8346375 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature