Ontology highlight
ABSTRACT:
SUBMITTER: Dussart-Gautheret J
PROVIDER: S-EPMC8703271 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20211215 24
This paper reports on the synthesis of new hydroxymethylene-(phosphinyl)phosphonates (HMPPs). A methodology has been developed to propose an optimized one-pot procedure without any intermediate purifications. Various aliphatic and (hetero)aromatic HMPPs were synthesized in good to excellent yields (53-98%) and the influence of electron withdrawing/donating group substitution on aromatic substrates was studied. In addition, the one-pot synthesis of HMPP was monitored by <sup>31</sup>P NMR spectro ...[more]