Synthesis of Highly Functionalizable Symmetrically and Unsymmetrically Substituted Triarylboranes from Bench-Stable Boron Precursors.

ABSTRACT: A novel and convenient methodology for the one-pot synthesis of sterically congested triarylboranes by using bench-stable aryltrifluoroborates as the boron source is reported. This procedure gives systematic access to symmetrically and unsymmetrically substituted triarylboranes of the types BAr₂ Ar' and BArAr'Ar'', respectively. Three unsymmetrically substituted triarylboranes as well as their iridium-catalyzed C-H borylation products are reported. These borylated triarylboranes contain one to three positions that can subsequently be orthogonally functionalized in follow-up reactions, such as Suzuki-Miyaura cross-couplings or Sonogashira couplings.

SUBMITTER: Ferger M 

PROVIDER: S-EPMC8360097 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature