Sequential targeting of PI3Kδ and LAG3 as an effective anti-cancer approach.
Ontology highlight
ABSTRACT: Emerging studies have demonstrated the potential of PI3Kδ blockade as an immunotherapy for solid tumours. In pre-clinical models, we recently demonstrated that anti-LAG3 immune checkpoint blockade vastly potentiated PI3Kδ-based immunotherapy, enabling successful tumour control in all treated mice.
SUBMITTER: Lauder SN
PROVIDER: S-EPMC8368216 | biostudies-literature |
REPOSITORIES: biostudies-literature
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