Amphiphilic Histidine-Based Oligopeptides Exhibit pH-Reversible Fibril Formation.
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ABSTRACT: We report the design, simulation, synthesis, and reversible self-assembly of nanofibrils using polyhistidine-based oligopeptides. The inclusion of aromatic amino acids in the histidine block produces distinct antiparallel β-strands that lead to the formation of amyloid-like fibrils. The structures undergo self-assembly in response to a change in pH. This creates the potential to produce well-defined fibrils for biotechnological and biomedical applications that are pH-responsive in a physiologically relevant range.
SUBMITTER: Noble Jesus C
PROVIDER: S-EPMC8375021 | biostudies-literature |
REPOSITORIES: biostudies-literature
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