Single-Particle Characterization of SARS-CoV-2 Isoelectric Point and Comparison to Variants of Interest.

ABSTRACT: SARS-CoV-2, the cause of COVID-19, is a new, highly pathogenic coronavirus, which is the third coronavirus to emerge in the past 2 decades and the first to become a global pandemic. The virus has demonstrated itself to be extremely transmissible and deadly. Recent data suggest that a targeted approach is key to mitigating infectivity. Due to the proliferation of cataloged protein and nucleic acid sequences in databases, the function of the nucleic acid, and genetic encoded proteins, we make predictions by simply aligning sequences and exploring their homology. Thus, similar amino acid sequences in a protein usually confer similar biochemical function, even from distal or unrelated organisms. To understand viral transmission and adhesion, it is key to elucidate the structural, surface, and

SUBMITTER: Areo O 

PROVIDER: S-EPMC8401476 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature