Dataset Information
Single particle cryo-EM of SARS-CoV-2 Spike protein in complex with the single chain fragment scFv76
Ontology highlight
ABSTRACT:
SUBMITTER: Antonio Chaves-Sanjuan
PROVIDER: EMPIAR-10990 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery.
Molecular therapy : the journal of the American Society of Gene Therapy 20220915 2
The uneven worldwide vaccination coverage against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and emergence of variants escaping immunity call for broadly effective and easily deployable therapeutic agents. We have previously described the human single-chain scFv76 antibody, which recognizes SARS-CoV-2 Alpha, Beta, Gamma and Delta variants. We now show that scFv76 also neutralizes the infectivity and fusogenic activity of the Omicron BA.1 and BA.2 variants. Cryoelectron microsco ...[more]