Dataset Information
Single particle cryo EM dataset of SARS-CoV-2 Spike protein with D614G substitution
Ontology highlight
ABSTRACT:
SUBMITTER: Donald Benton
PROVIDER: EMPIAR-10725 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.
Proceedings of the National Academy of Sciences of the United States of America 20210301 9
The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this substitution are associated with higher virus infectivity. We use cryo-electron microscopy to compare G614 and D614 spikes and show that the G614 mutant spike adopts a range of more open conformations that may facilitate binding to the SARS-CoV-2 receptor, ACE2, and the ...[more]