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Single particle cryo EM dataset of SARS-CoV-2 Spike protein with D614G substitution

ABSTRACT:

SUBMITTER: Donald Benton 

PROVIDER: EMPIAR-10725 | biostudies-other |

REPOSITORIES: biostudies-other

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The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2.

Benton Donald J DJ   Wrobel Antoni G AG   Roustan Chloë C   Borg Annabel A   Xu Pengqi P   Martin Stephen R SR   Rosenthal Peter B PB   Skehel John J JJ   Gamblin Steven J SJ  

Proceedings of the National Academy of Sciences of the United States of America 20210301 9

The majority of currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses have mutant spike glycoproteins that contain the D614G substitution. Several studies have suggested that spikes with this substitution are associated with higher virus infectivity. We use cryo-electron microscopy to compare G614 and D614 spikes and show that the G614 mutant spike adopts a range of more open conformations that may facilitate binding to the SARS-CoV-2 receptor, ACE2, and the  ...[more]

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