The gene expression patterns of neuronal cells reveal the pathogenesis of autism.

ABSTRACT:

Objective

To explore the effects of early comprehensive and specific behavioral interventions on improving social communication and attenuating anxiety in autism patients.

Methods

This study was based on the modular comprehensive analysis method and explored the neurotransmitter conduction mechanism in the pathogenesis of autism. We downloaded autism-related data from the Gene Expression Omnibus (GEO) database and performed a differential analysis, a co-expression Network Analysis (WGCNA) analysis, a GO function, and a KEGG pathway enrichment analysis. Finally, we predicted the non-coding RNAs (ncRNAs) and transcription factors (TFs) that regulate the module on the basis of hypergeometric testing.

Results

We obtained five co-expression modules, in which the active reg

SUBMITTER: Ding M 

PROVIDER: S-EPMC8430060 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature