Ontology highlight
ABSTRACT:
SUBMITTER: Yang CG
PROVIDER: S-EPMC2587245 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Yang Cai-Guang CG Yi Chengqi C Duguid Erica M EM Sullivan Christopher T CT Jian Xing X Rice Phoebe A PA He Chuan C
Nature 20080401 7190
Escherichia coli AlkB and its human homologues ABH2 and ABH3 repair DNA/RNA base lesions by using a direct oxidative dealkylation mechanism. ABH2 has the primary role of guarding mammalian genomes against 1-meA damage by repairing this lesion in double-stranded DNA (dsDNA), whereas AlkB and ABH3 preferentially repair single-stranded DNA (ssDNA) lesions and can repair damaged bases in RNA. Here we show the first crystal structures of AlkB-dsDNA and ABH2-dsDNA complexes, stabilized by a chemical c ...[more]