Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells.

ABSTRACT: The receptor tyrosine kinase, anexelekto (Axl) is involved in tumor cell growth, migration and invasion, and has been associated with chemotherapy resistance, which makes it an attractive target for cancer therapy. In total, six Axl-targeted monoclonal antibodies (mAbs) and two antibody-drug conjugates have been reported in the last 10 years, which have been shown to have bioactivity in inhibiting tumor cell proliferation and migration. The Axl external cell domain (Axl^-ECD), consisting of 426 amino acids, has always been used as an antigen in the screening process for all six of these Axl-targeted mAbs. However, the Axl functional domain, which interacts with its natural ligand, growth arrest-specific protein 6 (Gas6), is only a small part of the Axl^-ECD. Antibodies

SUBMITTER: Chang H 

PROVIDER: S-EPMC8436363 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature