Chronic low-grade inflammation in heart failure with preserved ejection fraction.
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ABSTRACT:
SUBMITTER: Mesquita T
PROVIDER: S-EPMC8441359 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Chronic low-grade inflammation in heart failure with preserved ejection fraction.
Mesquita Thassio T Lin Yen-Nien YN Ibrahim Ahmed A
Aging cell 20210812 9
Heart failure (HF) with preserved ejection fraction (HFpEF) is currently the predominant form of HF with a dramatic increase in risk with age. Low-grade inflammation, as occurs with aging (termed "inflammaging"), is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated HFpEF disease severity and better outcomes. From this perspective, inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease ...[more]
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