Ontology highlight
ABSTRACT:
SUBMITTER: Franz M
PROVIDER: S-EPMC8453727 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Franz Matthias M Mörchen Britta B Degenhart Carsten C Gülden Daniel D Shkura Oleksandr O Wolters Dirk D Koch Uwe U Klebl Bert B Stoll Raphael R Helfrich Iris I Scherkenbeck Jürgen J
ChemMedChem 20210519 16
Oncogenic Ras proteins are implicated in the most common life-threatening cancers. Despite intense research over the past two decades, the progress towards small-molecule inhibitors has been limited. One reason for this failure is that Ras proteins interact with their effectors only via protein-protein interactions, which are notoriously difficult to address with small organic molecules. Herein we describe an alternative strategy, which prevents farnesylation and subsequent membrane insertion, a ...[more]