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ABSTRACT:
SUBMITTER: Arribas A
PROVIDER: S-EPMC8456945 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20210720 35
We report a versatile, highly enantioselective intramolecular hydrocarbonation reaction that provides a direct access to heteropolycyclic systems bearing chiral quaternary carbon stereocenters. The method, which relies on an iridium(I)/bisphosphine chiral catalyst, is particularly efficient for the synthesis of five-, six- and seven-membered fused indole and pyrrole products, bearing one and two stereocenters, with enantiomeric excesses of up to >99 %. DFT computational studies allowed to obtain ...[more]