The taxonomic distribution of histamine-secreting bacteria in the human gut microbiome.

ABSTRACT:

Background

Biogenic histamine plays an important role in immune response, neurotransmission, and allergic response. Although endogenous histamine production has been extensively studied, the contributions of histamine produced by the human gut microbiota have not been explored due to the absence of a systematic annotation of histamine-secreting bacteria.

Results

To identify the histamine-secreting bacteria from in the human gut microbiome, we conducted a systematic search for putative histamine-secreting bacteria in 36,554 genomes from the Genome Taxonomy Database and Unified Human Gastrointestinal Genome catalog. Using bioinformatic approaches, we identified 117 putative histamine-secreting bacteria species. A new three-component decarboxylation system including two colocal

SUBMITTER: Mou Z 

PROVIDER: S-EPMC8465708 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature