Genetic associations of fatigue and other symptoms following breast cancer treatment: A prospective study.

ABSTRACT:

Background

Cancer-related fatigue, mood disturbances, pain and cognitive disturbance are common after adjuvant cancer therapy, but vary considerably between individuals despite common disease features and treatment exposures. A genetic basis for this variability was explored in a prospective cohort.

Methods

Physical and psychological health of women were assessed prospectively following therapy for early stage breast cancer with self-report questionnaires. Participation in a genetic association sub-study was offered. Indices for the key symptom domains of fatigue, pain, depression, anxiety, and neurocognitive difficulties were empirically derived by principal components analysis from end-treatment questionnaires, and then applied longitudinally. Genetic associations were sou

SUBMITTER: Cameron B 

PROVIDER: S-EPMC8474532 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature