Ontology highlight
ABSTRACT:
SUBMITTER: Qi M
PROVIDER: S-EPMC8550598 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Qi Meirigeng M Kaddis John S JS Chen Kuan-Tsen KT Rawson Jeffrey J Omori Keiko K Chen Zhen Bouman ZB Dhawan Sangeeta S Isenberg Jeffrey S JS Kandeel Fouad F Roep Bart O BO Al-Abdullah Ismail H IH
PloS one 20211027 10
We investigated the effect of chronic marijuana use, defined as 4 times weekly for more than 3 years, on human pancreatic islets. Pancreata from deceased donors who chronically used marijuana were compared to those from age, sex and ethnicity matched non-users. The islets from marijuana-users displayed reduced insulin secretion as compared to islets from non-users upon stimulation with high glucose (AUC, 3.41 ± 0.62 versus 5.14 ±0.47, p<0.05) and high glucose plus KCl (AUC, 4.48 ± 0.41 versus 7. ...[more]