Synthesis, cytotoxicity and docking studies (with SARS-CoV-2) of water-soluble binuclear Ru-p-cymene complex holding indole thiosemicarbazone ligand.

ABSTRACT: A water-soluble binuclear organometallic Ru-p-cymene complex [Ru(η⁶-p-cymene)(η²-L)]₂ (1) was prepared from (E)-2-((1H-indol-3-yl)methylene)-N-phenylhydrazine-1-carbothioamide (HL) and [RuCl₂(p-cymene)]₂ in methanol at room temperature under inert atmosphere. The structure of binuclear complex was analyzed by UV-Visible, FT-IR, NMR and mass spectroscopic methods. The solid-state structure of the complex was ascertained by single crystal X-ray diffraction technique. The complex exhibited pseudo-octahedral (piano-stool) geometry around Ru(II) ion. The cytotoxic property of the ligand and complex along with cisplatin was investigated against A549-lung, MCF-7-breast, HeLa-cervical, HepG-2-li

SUBMITTER: Haribabu J 

PROVIDER: S-EPMC8552700 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature