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Hydrogen bonding and anticancer properties of water-soluble chiral p-cymene Ru(II) compounds with amino-oxime ligands.

ABSTRACT: The investigation of the hydrogen-bonding effect on the aggregation tendency of ruthenium compounds [(?6-p-cymene)Ru(?NHR,?NOH)Cl]Cl (R = Ph (1a), Bn (1b)) and [(?6-p-cymene)Ru(?2NH(2-pic),?NOH)][PF6]2 (1c), [(?6-p-cymene)Ru(?NHBn,?NO)Cl] (2b) and [(?6-p-cymene)Ru(?NBn,?2NO)] (3b), has been performed by means of concentration dependence 1H NMR chemical shifts and DOSY experiments. The synthesis and full characterization of new compounds 1c, [(?6-p-cymene)Ru(?NPh,?2NO)] (3a) and 3b are also reported. The effect of the water soluble ruthenium complexes 1a-1c on cytotoxicity, cell adhesion and cell migration of the androgen-independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type-I-collagen and recovery of monolayer wounds assays, respectively. Interactions of 1a-1c with DNA and human serum albumin have also been studied. Altogether, the properties reported herein suggest that ruthenium compounds 1a-1c have considerable potential as anticancer agents against advanced prostate cancer.

SUBMITTER: Benabdelouahab Y 

PROVIDER: S-EPMC4862618 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature

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Hydrogen bonding and anticancer properties of water-soluble chiral <i>p</i>-cymene Ru(II) compounds with amino-oxime ligands.

Benabdelouahab Yosra Y   Muñoz-Moreno Laura L   Frik Malgorzata M   de la Cueva-Alique Isabel I   El Amrani Mohammed Amin MA   Contel María M   Bajo Ana M AM   Cuenca Tomás T   Royo Eva E  

European journal of inorganic chemistry 20150409 13

The investigation of the hydrogen-bonding effect on the aggregation tendency of ruthenium compounds [(η<sup>6</sup>-<i>p</i>-cymene)Ru(κNHR,κNOH)Cl]Cl (R = Ph (<b>1a</b>), Bn (<b>1b</b>)) and [(η<sup>6</sup>-<i>p</i>-cymene)Ru(κ<sup>2</sup>NH(2-<i>pic</i>),κNOH)][PF<sub>6</sub>]<sub>2</sub> (<b>1c</b>), [(η<sup>6</sup>-<i>p</i>-cymene)Ru(κNHBn,κNO)Cl] (<b>2b</b>) and [(η<sup>6</sup>-<i>p</i>-cymene)Ru(κNBn,κ<sup>2</sup>NO)] (<b>3b</b>), has been performed by means of concentration dependence <su  ...[more]

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