Hydrogen bonding and anticancer properties of water-soluble chiral p-cymene Ru(II) compounds with amino-oxime ligands.

ABSTRACT: The investigation of the hydrogen-bonding effect on the aggregation tendency of ruthenium compounds [(?6-p-cymene)Ru(?NHR,?NOH)Cl]Cl (R = Ph (1a), Bn (1b)) and [(?6-p-cymene)Ru(?2NH(2-pic),?NOH)][PF6]2 (1c), [(?6-p-cymene)Ru(?NHBn,?NO)Cl] (2b) and [(?6-p-cymene)Ru(?NBn,?2NO)] (3b), has been performed by means of concentration dependence 1H NMR chemical shifts and DOSY experiments. The synthesis and full characterization of new compounds 1c, [(?6-p-cymene)Ru(?NPh,?2NO)] (3a) and 3b are also reported. The effect of the water soluble ruthenium complexes 1a-1c on cytotoxicity, cell adhesion and cell migration of the androgen-independent prostate cancer PC3 cells have been assessed by MTT, adhesion to type-I-collagen and recovery of monolayer wounds assays, respectively. Interactions of 1a-1c with DNA and human serum albumin have also been studied. Altogether, the properties reported herein suggest that ruthenium compounds 1a-1c have considerable potential as anticancer agents against advanced prostate cancer.

SUBMITTER: Benabdelouahab Y 

PROVIDER: S-EPMC4862618 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature