Unknown

Dataset Information

0

Robust Virus-Specific Adaptive Immunity in COVID-19 Patients with SARS-CoV-2 Δ382 Variant Infection.


ABSTRACT: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) that have become dominant as the pandemic progresses bear the ORF8 mutation together with multiple spike mutations. A 382-nucleotide deletion (Δ382) in the ORF7b and ORF8 regions has been associated with milder disease phenotype and less systemic inflammation in COVID-19 patients. However, its impact on host immunity against SARS-CoV-2 remains undefined. Here, RNA-sequencing was performed to elucidate whole blood transcriptomic profiles and identify contrasting immune signatures between patients infected with either wildtype or Δ382 SARS-CoV-2 variant. Interestingly, the immune landscape of Δ382 SARS-CoV-2 infected patients featured an increased adaptive immune response, evidenced by enrichment of genes related to T cell functionality, a more robust SARS-CoV-2-specific T cell immunity, as well as a more rapid antibody response. At the molecular level, eukaryotic initiation factor 2 signaling was found to be upregulated in patients bearing Δ382, and its associated genes were correlated with systemic levels of T cell-associated and pro-inflammatory cytokines. This study provides more in-depth insight into the host-pathogen interactions of ORF8 with great promise as a therapeutic target to combat SARS-CoV-2 infection.

SUBMITTER: Fong SW 

PROVIDER: S-EPMC8556776 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7803150 | biostudies-literature
| S-SCDT-EMM-2022-15904 | biostudies-other
| S-EPMC7494270 | biostudies-literature
| S-EPMC7774536 | biostudies-literature
| S-EPMC8754314 | biostudies-literature
2023-11-21 | GSE247917 | GEO
| S-EPMC7610739 | biostudies-literature
| S-EPMC7899452 | biostudies-literature
| S-EPMC8299217 | biostudies-literature