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Enantioselective palladaelectro-catalyzed C–H olefinations and allylations for N–C axial chirality† † Electronic supplementary information (ESI) available. CCDC 2090275. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1sc04687j

ABSTRACT: Enantioselective palladaelectro-catalyzed C–H alkenylations and allylations were achieved with easily-accessible amino acids as transient directing groups. This strategy provided access to highly enantiomerically-enriched N–C axially chiral scaffolds under exceedingly mild conditions. The synthetic utility of our strategy was demonstrated by a variety of alkenes, while the versatility of our approach was reflected by atroposelective C–H allylations. Computational studies provided insights into a facile C–H activation by a seven-membered palladacycle. Enantioselective palladaelectro-catalyzed C–H alkenylations and allylations were achieved by the means of an easily-accessible amino acid for the synthesis of N–C axially chiral indole biaryls.

SUBMITTER: Dhawa U

PROVIDER: S-EPMC8565398 | biostudies-literature |

REPOSITORIES: biostudies-literature

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