A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles.
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ABSTRACT:
SUBMITTER: Teh JH
PROVIDER: S-EPMC8567295 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Publications
A kit-based aluminium-[<sup>18</sup>F]fluoride approach to radiolabelled microbubbles.
Teh Jin Hui JH Braga Marta M Allott Louis L Barnes Chris C Hernández-Gil Javier J Tang Meng-Xing MX Tang Meng-Xing MX Aboagye Eric O EO Long Nicholas J NJ
Chemical communications (Cambridge, England) 20211104 88
The production of <sup>18</sup>F-labelled microbubbles (MBs) <i>via</i> the aluminium-[<sup>18</sup>F]fluoride ([<sup>18</sup>F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) 'click' chemistry is reported. An [<sup>18</sup>F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a <i>trans</i>-cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). T ...[more]
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