Multiple bacterial virulence factors focused on adherence and biofilm formation associate with outcomes in cirrhosis.

ABSTRACT:

Background & aims

Altered gut microbiota is associated with poor outcomes in cirrhosis, including infections and hepatic encephalopathy (HE). However, the role of bacterial virulence factors (VFs) is unclear. Aim: Define association of VFs with cirrhosis severity and infections, their linkage with outcomes, and impact of fecal microbiota transplant (FMT).

Methods

VF abundances were determined using metagenomic analysis in stools from controls and cirrhosis patients (compensated, HE-only, ascites-only, both and infected). Patients were followed for 90-day hospitalizations and 1-year death. Stool samples collected before/after a placebo-controlled FMT trial were also analyzed. Bacterial species and VFs for all species and selected pathogens (Escherichia, Klebsiella, Pseudom

SUBMITTER: Bajaj JS 

PROVIDER: S-EPMC8582993 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature