Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution.

ABSTRACT:

Purpose

To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B₀ = 9.4 T. ²H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects.

Methods

The study was performed with a double-tuned coil with 10 TxRx channels for ¹H and 8TxRx/2Rx channels for ²H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min.

Results

The metabolism of [6,6'-²H₂]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain.

Conclusion

X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.

SUBMITTER: Ruhm L 

PROVIDER: S-EPMC8591372 | biostudies-literature |

REPOSITORIES: biostudies-literature