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Core Steps to the Azaphilone Family of Fungal Natural Products.


ABSTRACT: Azaphilones are a family of polyketide-based fungal natural products that exhibit interesting and useful bioactivities. This minireview explores the literature on various characterised azaphilone biosynthetic pathways, which allows for a proposed consensus scheme for the production of the core azaphilone structure, as well as identifying early diversification steps during azaphilone biosynthesis. A consensus understanding of the core enzymatic steps towards a particular family of fungal natural products can aid in genome-mining experiments. Genome mining for novel fungal natural products is a powerful technique for both exploring chemical space and providing new insights into fungal natural product pathways.

SUBMITTER: Williams K 

PROVIDER: S-EPMC8596599 | biostudies-literature |

REPOSITORIES: biostudies-literature

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2022-01-06 | ST002482 | MetabolomicsWorkbench