Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the K_V1.3 Ion Channel Independent of Membrane Cholesterol Extraction.

ABSTRACT: Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming water-soluble complexes with a variety of otherwise poorly soluble molecules including cholesterol and different drugs. Consistently, CDs are widely used in research and clinical practice to deplete cholesterol from cellular membranes or to increase solubility and bioavailability of different pharmaceuticals at local concentrations in the millimolar range. Effects of CDs exerted on cellular functions are generally thought to originate from reductions in cholesterol levels. Potential direct, ligand-like CD effects are largely neglected in spite of several recent studies reporting direct interaction between CDs and proteins including AMP-activated protein kinase, β-amyloid peptides, and α-synuclein. In this study, by using pa

SUBMITTER: Kovacs T 

PROVIDER: S-EPMC8599428 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature