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Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S


ABSTRACT: Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed product, RTS,S/AS01. The main contributions of modelling studies have been in inferring the mechanism of action and efficacy profile of RTS,S; to predicting the public health impact; and economic modelling mainly comprising cost-effectiveness analysis. The value of both product-specific and generic modelling of vaccines is highlighted.

Supplementary Information

The online version contains supplementary material available at 10.1186/s12936-021-03973-y.

SUBMITTER: Galactionova K 

PROVIDER: S-EPMC8600337 | biostudies-literature |

REPOSITORIES: biostudies-literature

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