Exploiting lipotoxicity for the treatment of liver cancer.
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ABSTRACT: Metabolic alterations occur frequently in solid tumours, but metabolic cancer therapies are limited by the complexity and plasticity of metabolic networks. We could recently show that activation of the liver X receptor alpha (LXRα) and inhibition of a Raf-1-SCD1 protein complex induces an intracellular accumulation of saturated free fatty acids leading to lethal lipotoxicity in tumour cells and allows for an efficient treatment of liver carcinomas.
SUBMITTER: Rudalska R
PROVIDER: S-EPMC8608911 | biostudies-literature |
REPOSITORIES: biostudies-literature
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