Ontology highlight
ABSTRACT:
SUBMITTER: Safitri FA
PROVIDER: S-EPMC8615816 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Safitri Fika Ayu FA Tu Anh Thi Tram ATT Hoshi Kazuaki K Shobo Miwako M Zhao Dandan D Witarto Arief Budi AB Sumarsono Sony Heru SH Giri-Rachman Ernawati Arifin EA Tsukakoshi Kaori K Ikebukuro Kazunori K Yamazaki Tomohiko T
Biomolecules 20211101 11
Guanine-quadruplex-based CpG oligodeoxynucleotides (G4 CpG ODNs) have been developed as potent immunostimulatory agents with reduced sensitivity to nucleases. We designed new monomeric G4 ODNs with an antiparallel topology using antiparallel type duplex/G4 ODNs as robust scaffolds, and we characterized their topology and effects on cytokine secretion. Based on circular dichroism analysis and quantification of mRNA levels of immunostimulatory cytokines, it was found that monomeric antiparallel G4 ...[more]